David Sharir was born in Tel Aviv in 1938 to parents of Russian descent. He began drawing as a child. He studied for six months at the Avni Institute, and later studied with artists such as Joseph Zeritzky, Yochanan Simon, and especially with Israel Paldi. After his military service, he went to study in Italy. He studied art and architecture, but did not finish his degree. In 1966 he was one of the first artists to settle in the Artists' Quarter in Old Jaffa.
Most of his work is in painting. His figurative works describe landscape or literary images in a stylized way. In 1996, the Shalom Tower in Tel Aviv-Jaffa was decorated with a wall mosaic of his design, with an image of the city.