Uri Lifshitz was born and raised in Kibbutz Givat Hashlosha. Lifshitz began painting in the late 1950s. Lifshitz is considered a prolific artist and his works are exhibited in many exhibitions. He won many prizes, including the Chagall Prize awarded by Marc Chagall in 1966 and the Dizengoff Prize in 1982.
He lived in the Ajami neighborhood in Jaffa and Neve Tzedek neighborhood.
In his early years, Lifshitz painted mainly in an abstract style. He himself declared that he did not study painting because he can not study and he believes that there are people who need to learn and some people do not have to learn. But some saw him as an apprentice of Yosef Zaritsky and one of the students of the New Horizons school.
Sometimes his works and remarks touched upon controversial social issues, like sexuality and mentality.